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IUPUI School of Engineering and Technology

IUPUI School of Engineering and Technology

Chien-Chi Lin

  • Associate Professor of Biomedical Engineering
Chien-Chi Lin

317-274-0760
SL 220K
lincc@iupui.edu
Professional Website

Education

  • Clemson University, Bioengineering, Ph.D., 2007

Professional Experience

  • Assistant Professor, Department of Biomedical Engineering, Indiana University-Purdue University Indianapolis, 8/2010 - 6/2016
  • Postdoctoral Associate, Department of Chemical & Biological Engineering, Howard Hughes Medical Institute & University of Colorado at Boulder, 9/2007 - 7/2010
  • Graduate Research Assistant, Department of Bioengineering, Clemson University, 8/2004 - 8/2007

Selected Publications

  • Dawes CS, Konig H, and Lin CC*. Enzyme-immobilized hydrogels to create hypoxic environment for in vitro cancer cell culture. Journal of Biotechnology 2017(248) 25-34, 3/2017
  • Shih H, Liu HY, and Lin CC*. Improving gelation efficiency and cytocompatibility of visible light polymerized thiol-norbornene hydrogels via addition of soluble tyrosine. Biomaterials Science 2017 (5) 589-599 ​ , 2/2017
  • Greene T, Lin TY, Andrisani O, and Lin CC*. Comparative study of visible light polymerized gelatin hydrogels for 3D culture of hepatic progenitor cells. Journal of Applied Polymer Science 2017(134) 44585, 1/2017
  • Liu HY, Greene T, Lin TY, Dawes CS, Korc M, and Lin CC*. Enzyme-mediated stiffening hydrogels for probing activation of pancreatic stellate cells. Acta Biomaterialia 2017 (48) 258-269, 1/2017
  • Shih H, Greene T, Korc M, and Lin CC*. Modular and adaptable tumor niche prepared from visible light-initiated thiol-norbornene photopolymerization. Biomacromolecules 2016 (17) 3872-3882, 12/2016
  • Shih H and Lin CC*. Tuning stiffness of cell-laden hydrogels via host-guest interactions. Journal of Materials Chemistry B 2016(4)​4969-4974​. (Featured Cover Art), 6/2016
  • Lin TY, Bragg JC, and Lin CC*. Designing visible light cured thiol-acrylate hydrogels for studying HIPPO pathway activation in hepatocellular carcinoma cells. Macromolecular Bioscience 2016(16) 496-507 , 2/2016
  • Shih H and Lin CC*. Photoclick hydrogels prepared from functionalized cyclodextrin and poly(ethylene glycol) for drug delivery and in situ cell encapsulation. Biomacromolecules 2015(16) 1915-1923, 6/2015
  • Lin CC*, Ki CS, Shih H. Thiol-norbornene photo-click hydrogels for tissue engineering applications. Journal of Applied Polymer Science 2015(132) 41563 (Featured Cover Art), 1/2015
  • Shih H, Mirmira RG, and Lin CC*. Visible light-initiated interfacial thiol-ene photopolymerization for forming islet surface conformal coating. Journal of Material Chemistry B 2015(3) 170-175, 1/2015
  • Lin CC*. Recent advances in crosslinking chemistry of biomimetic poly(ethylene glycol) hydrogels. RSC Advances 2015(5) 39844-398583, 1/2015
  • Ki CS, Lin TY, Korc M, and Lin CC*. Thiol-ene hydrogels as desmoplasia-mimetic matrices for modeling pancreatic cancer cell growth, invasion, and drug resistance. Biomaterials 2014(35) 9668-9677, 11/2014
  • Lin TY, Ki CS, and Lin CC*. Manipulating hepatocellular carcinoma cell fate in orthogonally cross-linked hydrogels. Biomaterials 2014(35) 6898-6906, 7/2014
  • Munoz Z§, Shih H§, and Lin CC*. Gelatin hydrogels formed by orthogonal thiol-norbornene photochemistry for cell encapsulation. Biomaterials Science 2014(2) 1063-1072 (§Equal contribution/Featured Cover Art), 4/2014
  • Fraser AK§, Ki CS§, and Lin CC*. PEG-based microgels formed by visible light mediated thiol-ene photo-click reactions. Macromolecular Chemistry & Physics 2014(215) 507-515 (§Equal contribution) , 2/2014
  • Hao Y, Shih H, Munoz Z, Kemp A, Lin CC*. Visible light cured thiol-vinyl hydrogels with tunable degradation for 3D cell culture. Acta Biomaterialia 2014(10) 104-114, 1/2014
  • Ki CS, Shih H, and Lin CC*. Effect of 3D matrix compositions on the efficacy of EGFR inhibitor in pancreatic ductal adenocarcinoma cells. Biomacromolecules 2013(14) 3017-3026, 12/2013
  • Raza A and Lin CC*. The influence of hydrogel degradation and functionality on cell survival and morphogenesis in PEG-based hydrogels. Macromolecular Bioscience 2013(13) 1048-1058 , 10/2013
  • Raza A, Ki CS, and Lin CC*. The influence of matrix properties on growth and morphogenesis of pancreatic ductal epithelial cell in 3D. Biomaterials 2013(34) 5117-5127, 6/2013
  • Shih H, Fraser AK, and Lin CC*. Interfacial thiol-ene photo-click reactions for forming multilayer hydrogels. ACS Applied Materials & Interfaces 2013(5) 1673-1680, 2/2013
  • Shih H and Lin CC*. Visible light-mediated thiol-ene hydrogelation using eosin-Y as the only photoinitiator. Macromolecular Rapid Communications 2013(34) 269-273, 1/2013
  • Shih H and Lin CC*. Crosslinking and degradation of step-growth hydrogels formed by thiol-ene photo-click chemistry. Biomacromolecules 2012(13) 2003-2012, 1/2012
  • Lin CC*, Raza A, Shih H. PEG hydrogels formed by thiol-ene photo-click chemistry and their effect on the formation and recovery of insulin-secreting cell spheroids. Biomaterials 2011(32) 9685-9695., 1/2011
  • Lin CC* and Anseth KS*. Cell-cell communication mimicry with PEG hydrogels for enhancing β-cell function. The Proceedings of the National Academy of Sciences USA 2011(108) 6380-6385 -Highlighted on Nature SciBX 4(16)., 11/2010

Awards, Honors, and Certifications

  • Honorary Scientist and Advisor on Agricultural Science & Technology, the Rural Development Administration of the Republic of Korea, 7/2017
  • US Frontiers of Engineering Symposium Invitee, National Academy of Engineering, 9/2015
  • Faculty Early Career Development (CAREER) Award, National Science Foundation, 7/2015
  • Purdue Summer Faculty Research Grant, Purdue Research Foundation, 7/2014
  • Young Investigator Award, Frontiers in Bioengineering Workshop, Georgia Institute of Technology, 2/2013
  • American Institute of Chemists Postdoctoral Award, University of Colorado , 7/2010
  • Outstanding Graduate Research Assistant Award, Graduate School & Clemson University Research Foundation, 7/2007
  • Outstanding Graduate Researcher Award, College of Engineering & Science,Clemson University , 7/2007

Expertise

Biomaterials, photopolymerizations, tissue engineering, bioconjugate chemistry

Interests

We are interested in designing multifunctional polymeric biomaterials for studying cancer cell biology, for releasing drugs and growth factors, and for delivering therapeutically relevant cells for tissue engineering and regenerative medicine applications. ​Our research projects are highly interdisciplinary and integrate knowledge from polymer chemistry and engineering, bioconjugate chemistry, biochemistry, cell and molecular biology, and immunology.