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IUPUI School of Engineering and Technology

IUPUI School of Engineering and Technology

Advanced Biomolecular Engineering

BME 69500 / 3 Cr.

One of the most challenging tasks for the current biomedical engineers is to extract biologically important information from a large amount of data such as genomic DNA sequences and mRNA/protein expression data. Using examples in human genomics and proteomics, this course describes cutting-edge biomolecular technologies, computational algorithms, and mathematical models. The first half is genomics focusing on experimental designs with microarrays and analyses of microarray-derived data, and the second half is proteomics focusing on the principles of mass spectrometry and analyses of protein expression data. The subjects include structure of human genome, DNA microarrays, cluster analyses, singular value decomposition, modeling and voting, mass spectroscopy, protein arrays, systems biology, and biostatistics.

Textbooks

There are no required textbooks. Handouts and journal articles are made available to the students.

Recommended Reading
  • Ideker, T. et al. Ann. Rev. Gen. Hum. Genet. 2:343-372 (2001)
  • Ideker, T. et al. Science 292:929-934 (2001)
  • Churchill, G.A. et al. Nature Genetics 32:490-495 (2002)
  • Eisen, M.B. et al. PNAS 95:14863-14868 (1998)
  • Khan, J. et al. Cancer Res. 58:5009-5013 (1998)
  • Alter, O. et al. PNAS 97:10101-10106 (2000)
  • Shipp, M.A. et al. Nature Medicine 8:68-74 (2002)
  • Yates, J.R. TIG 16:5-8 (2000)
  • Griffin , T.J., and Aebersold, R. JBC 276:45497-45500 (2001)
  • Harris, R.A. Proteomics 2:212-223 (2002)
  • Haab et al. Genome Biology 2:4.1-4.13 (2001)
  • Tong, A.H.Y. et al. Science 295:321-324 (2002)
  • Ho et al. Nature 415:180-183 (2002)