Purdue School of Engineering and Technology

Purdue School of Engineering and Technology

Quantitative Physiology

BME 41100 / 3 Cr.

BME 41100 is an introductory course in physiological systems and an introductory course in classical feedback control theory for biomedical engineers. It aims to apply systems theory and classical feedforward and feedback control in the context of physiological systems. Approximately a third of the course will be devoted to physiological systems, a third to classical control theory and a third to the application of classical control and systems theory to physiological systems.


Dorf, Bishop, Modern Control Systems 11/e, Prentice Hall, ISBN: 978-0-13-227028-1 or 12/e, ISBN: 978-0-13-602458-3. Boron & Boulpaep, Medical Physiology 2/e, Saunders, ISBN: 978-1-4160-3115-4.


Matlab & Simulink Student Version


After completion of this course the successful student should be able to:

  • Describe major physiological features of the peripheral nervous system, skeletal muscle, and other physiological systems. [l]
  • Analyze and model dynamic physiological systems from the literature using linear systems techniques. [a,b,c,l,m]
  • Design feedback controllers for linear systems.[a,e]
  • Analyze the stability of a system that relies on feedback.[a,e]
  • Analyze frequency response and construct Bode plots.[a,k]
  • Work in teams to understand and implement a model of a physiological system. [d]

(roughly by lectures, order may vary)

  • Review of Linear Systems (C)
  • Resting Membrane Potentials (P)
  • Poles and Zeros (C)
  • Action Potentials (P)
  • Time Domain Specifications (C)
  • Peripheral Nervous System (P)
  • Skeletal Muscles (P)
  • Dynamic Response, Stability (C)
  • Synaptic Transmission, Neuromuscular Junction (P)
  • Feedback Controllers (C)
  • Muscle Afferents (P)
  • Frequency Domain Analysis, Bode Plots, Root Locus (C)
  • Smoot and Cardiac Muscles (P)
  • System Identification (C)
  • Somatosensory System (P)
  • Special Systems (P)
  • Physiological Control Systems
  • Homework (5%)
  • Exam 1 (15%)
  • Exam 2 (15%)
  • Group Project (25%)
  • Presentations (10%)
  • Final Exam (30%)