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IUPUI School of Engineering and Technology

IUPUI School of Engineering and Technology

Problems in Implantable Materials & Biological Response

BME 38300 / 1 Cr.

BME 38300 is a corequisite course to BME 38100, supplementing the basic science of BME 38100 with quantitative, analytical examples and problems related to fundamental engineering principles in implantable materials. Topics include: microstructure, phase transformation, processing and design issues related to major engineering materials used for implantation purposes.

Textbooks

Materials Science and Engineering: An Introduction, 8th Ed. by W. D. Callister, Jr., (2009), John Wiley & Sons, Inc. ISBN: 978-0-470-41997-7

Goals

To develop the engineering principles behind the microstructure-property-processing relationship in implantable materials.

Outcomes

After completion of this course, students are expected to:

  • Better understand interactions between implantable biomaterials and tissues
  • Know sample processing and testing techniques in major biomaterial categories
  • Know how to select and use basic biomechanical tests to evaluate the properties of biomaterial
Topics
  • Overview of implantable materials & their biological responses
  • Analysis of interactions between implantable materials and tissue
  • Applying in vitro and in vivo compatibility tests
  • Applying fundamental engineering tools to characterize interactions between implants and tissue
Hands-on Experience and Quantitative Analysis
  • Polymeric hydrogel biophysical properties
  • Ceramic cement biophysical and mechanical properties
  • Relationship of heat treatment and metal properties
  • Estimation and verification of composite material properties
Additional Reading Materials

Tissue-Biomaterial Interactions, K.C. Dee, D.A. Puleo, R. Bizios. ISBN 0-471-25394-4. Printed handouts related to special topics will be provided.