IUPUI School of Engineering and Technology

IUPUI School of Engineering and Technology

Implantable Materials & Biological Response

BME 38100 / 3 Cr.

BME 38100 combines biomaterials, their biological response, and interactions between implantable materials and biological systems. Materials science of implantable materials; overview of implantable biomaterials and interactions between implants and biosystem; in vitro and in vivo biocompatibility tests; and specific examples on implant-tissue interactions, biocompatibility, and evaluation tools are presented.


Biomaterials: The Intersection of Biology and Materials Science (1st Edition, Pearson), by Temenoff and Mikos (ISBN-13: 978-0-13-009710-1). Janeway’s Immunobiology (8th Edition, Garland Science), by Kenneth Murphy (ISBN 978-0-8153-4243-4) (italicized chapter numbers).


To help students know implantable biomaterials and better understand interactions between the implants and biosystem.


After completion of the course students are expected to know basic implantable biomaterials, understand interactions between implantable biomaterials and tissues, know how to select and use basic in vitro and vivo biocompatibility tests to evaluate the tissue response to the implantable biomaterials, and know how to characterize the interfaces between the implant and biosystem.

  • Overview of basic materials science
  • Chemical structures and physical properties of implantable materials
    • Metals/Ceramics/Polymers/Composites
    • Biological materials
  • Tissue response to implants
  • Blood and clotting
  • Immunological response
    • Innate immunity
    • Adaptive immunity
  • Degradation of implantable materials
  • Surface properties of implantable materials
    • Protein-material interactions
    • Cell-material interactions
  • Implantable materials processing, characterizations, and sterilization
  • Biocompatibility & Tissue engineering
  • Hypersensitivity
  • Tumorigenesis, transplantation and tolerance
  • Biofilms
  • Wound healing
  • Manipulation of the immune response
Additional Reading Materials
  • Biomaterials Science: An Introduction to Materials in Medicine (2nd Edition, ELSEVIER) by Ratner, Hoffman, Schoen, and Lemons
  • An Introduction to Tissue-Biomaterials Interactions (1st Edition, Wiley-Liss) Dee, Puleo, and Bizios