IUPUI School of Engineering and Technology

IUPUI School of Engineering and Technology

Problems in Cell/Tissue Behavior & Properties

BME 35400 / 1 Cr.

This course develops quantitative biomechanical methods to analyze cell/tissue behavior and properties and to solve biomechanical engineering problems. Topics include: molecular and cellular basis for mechanotransduction, mechanobiology in skeletal and cardiovascular tissues, and molecular/cellular experiments. Students will solve problems appropriate for the class materials, and conduct experiments in the area of molecular/cellular engineering.


Through problem sets and bioengineering experiments, introduce students to quantitative methods to analyze cell/tissue behavior and properties.


After completion of this course, students should be able to:

  • Formulate elasticity and viscosity in biological system. [e]
  • Determine stress and strain. [a4]
  • Evaluate failure load. [a4]
  • Evaluate forces acting on a cell. [a]
  • Formulate dynamics in cell adhesion and migration. [e]
  • Model cellular responses to mechanical stimuli. [e]
  • Conduct experiments and analyze data as a team. [d]
  • Molecular and cellular mechanics
  • Mechanics of the cytoskeleton
  • Stress and strain
  • Bone mechanics: extension and torsion
  • Bone mechanics: bending
  • Molecular engineering experiments
Recommended Reference Books
  • Mechanics of Motor Proteins and the Cytoskeleton by Jonathon Howard (2001), Sinauer Associates, Inc. Publishers (ISBN 978-0-87893-333-4).
  • An Introduction to Biomechanics by Jay D. Humphrey and Sherry L. Delange (2004) Springer-Verlag New York, Inc. (ISBN 0-387-40249-7).