Problems in Cell/Tissue Behavior & Properties
BME 35400 / 1 Cr.
This course develops quantitative biomechanical methods to analyze cell/tissue behavior and properties and to solve biomechanical engineering problems. Topics include: molecular and cellular basis for mechanotransduction, mechanobiology in skeletal and cardiovascular tissues, and molecular/cellular experiments. Students will solve problems appropriate for the class materials, and conduct experiments in the area of molecular/cellular engineering.
Available Online: No
Credit by Exam: No
Laptop required: No
P: BME 24100. C: BME 35200.
Through problem sets and bioengineering experiments, introduce students to quantitative methods to analyze cell/tissue behavior and properties.
After completion of this course, students should be able to:
- Formulate elasticity and viscosity in biological system. [e]
- Determine stress and strain. [a4]
- Evaluate failure load. [a4]
- Evaluate forces acting on a cell. [a]
- Formulate dynamics in cell adhesion and migration. [e]
- Model cellular responses to mechanical stimuli. [e]
- Conduct experiments and analyze data as a team. [d]
- Molecular and cellular mechanics
- Mechanics of the cytoskeleton
- Stress and strain
- Bone mechanics: extension and torsion
- Bone mechanics: bending
- Molecular engineering experiments
Recommended Reference Books
- Mechanics of Motor Proteins and the Cytoskeleton by Jonathon Howard (2001), Sinauer Associates, Inc. Publishers (ISBN 978-0-87893-333-4).
- An Introduction to Biomechanics by Jay D. Humphrey and Sherry L. Delange (2004) Springer-Verlag New York, Inc. (ISBN 0-387-40249-7).